The state of current research into stem cell treatments for fetal birth defects. Presented by Diana Farmer, MD, Division Chief of UCSF Pediatric Surgery and Professor, UCSF Fetal Treatment Center
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Potential of Stem Cell Treatments for Autism

In June of 2007 an article was published in a peer-reviewed journal (1) proposing a role for stem cell therapy in treating autism. The account that follows provides a perspective on the implications and prevalence of autism, as well as a synopsis and a critique of the proposed use of stem cells to treat the major symptoms of autism disorder.

Autism

Autism is a complex brain developmental disorder that is characterised by impaired social interactions, communication difficulties, obsessive attachment to routines and repetition, and often an extreme dislike of certain sounds, textures and tastes. Autism usually surfaces in the first three years of life and may vary in severity from mild to disabling. Depending on degree of severity, some children with autism may develop into independent adults with full time employment and self-sufficiency; however this is seldom the case (2). There is no known single cause but abnormalities in brain function are generally attributed to environmental, immunological and neurological factors.

Social costs

It is reported as one of the fastest-growing developmental disabilities in the US, with diagnoses having increased by staggering proportions in the last decade (2). An estimated 1.5 million children and adults in the U.S. currently (as at 2007) have some form of autism (2). Presenting these statistics another way; autism spectrum disorders are believed to affect approximately 1 in 166 children (1).

Children with autism suffer from two major conditions: Hypoperfusion and Immune Dysregulation

Hypoperfusion of the brain in autism

Children with autism have shown impaired blood flow (hypoperfusion) to the brain. Hypoperfusion may contribute to functional defects not only by inducing hypoxia (an oxygen deficit that prevents normal brain function) but also by allowing for abnormal metabolite or neurotransmitter accumulation. Hypothetically, if perfusion can be improved through the revitalisation of blood vessels (angiogenesis), then this should also allow for metabolite clearance and restoration of functionality.

Immune dysregulation in autism

Successful neurodevelopment is contingent upon a normal balanced immune response. Children with autism have immune systems that do not function normally; instead an autoimmune response of the nervous system appears to prevail (3). Astrocytes (supportive brain cells) that normally play a critical role in regulating perfusion [reviewed in 1] and protection against central nervous system infection, have the potential to cause damage to the host when functioning in an aberrant (i.e. auto-immune) manner. Autistic children often have continually suppressed immune systems and chronic inflammation. Immune dysregulation

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www.timesonline.co.uk/tol/life_and_style/health/article1637528.ece

“Diabetics using stem-cell therapy have been able to stop taking insulin injections for the first time, after their bodies started to produce the hormone naturally again.

In a breakthrough trial, 15 young patients with newly diagnosed type 1 diabetes were given drugs to suppress their immune systems followed by transfusions of stem cells drawn from their own blood…..”

Try tell us what you think about this issue without bashing, Thanks! Love ya all!

Best answer:

Answer by ZER0 C00L™
I don’t think they have a problem with stem cells “drawn from their own blood”, but they do have a problem getting stem cells from 150 cell embryos which are created and then prevented from developing.

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This book will be the only current practical guide to a widely used procedure for treating leukemias and disseminated cancers. The contents are organized chronologically, to serve as a step-by-step guide throughout the transplant process. Comprehensive yet concise, it emphasizes the latest techniques, such as peripheral blood stem cell grafts.

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AUTOHEMOTHERAPY REFERENCE MANUAL (The AUTOMED Project)

AUTOBLOOD – THE MAGIC SHOT
DEFINITIVE GUIDE AND HISTORICAL REVIEW
FROM BLOODLETTING TO STEM CELLS

auto (self) -hemo (blood) – therapy

Learn why bloodletting reigned as the supreme therapy throughout the history of medicine, and how the mechanism of autohemotherapy may be at least partly responsible for its purported beneficial effects.

View modern trends involving the use of bone-marrow and stem-cells, and how these “state-of-the-art” therapies intimately relate to aut

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This is an informative reference to the technological advances, applications, and issues of stem cell research. The past few years have seen controversy and debate surrounding stem cell research. Because skin cells have the capability to divide – unlike most of the cells in our body – our skin can heal itself through the division of cells. Scientists have attempted to apply this concept to major organs, trying to see if stem cells can be used to make the repairs that post-mitotic cells cannot. ”

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Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus bank

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Oxygen and Ozone therapy is a powerful method of flooding your body life giving oxygen and of regenerating your cells for true anti aging. Find out why oxygen and ozone therapies are powerful for anti aging and how you can use them today for your health benefit and to reverse your aging process.
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Learn What Steps are Involved in Developing Therapies with Embryonic Stem Cells, and What Hurdles Must Be Overcome to Do So [Science] [Show ID: 12682]
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This is a preview of Regenerative Medicine with Placenta Extracts and Stem Cell Therapies by Dr. Janethy Balakrishnan at the 2008A4M Orlando Conference. Visit www.instatapes.com to purchase this lecture and many others on DiGiVision, video and slides synced. Also, visit www.worldhealth.net for the conference sponsor. Item #A5M-081W07

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Welcome to Stem Cell Therapies. Stem cell therapies refer to treatments which are a type of genetic medicine that introduce new cells into damaged tissue in order to treat a disease or injury. Many medical researchers believe that stem cell treatments have the potential to change the face of human disease and alleviate suffering. The ability of stem cells to self-renew and give rise to subsequent generations that can differentiate offers a large potential to culture tissues that can replace diseased and damaged tissues in the body, without the risk of rejection and side effects.

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A number of stem cell therapies exist, although most are still experimental and/or costly, with the notable exception of bone marrow transplantation. Medical researchers anticipate one day being able to use technologies derived from adult and embryonic stem cell research to treat cancer, Type 1 diabetes mellitus, Parkinson’s disease, Huntington’s disease,Celiac Disease, cardiac failure, muscle damage and neurological disorders, along with many others.

More research is needed concerning both stem cell behavior and the mechanisms of the diseases they could be used to treat before most of these experimental stem cell therapies become realities.

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